Chinese Wuhan Virus Thread


Senior member
Dec 3, 2017

Zydus Cadila: India approves world's first DNA Covid vaccine​

India's drug regulator has approved the world's first DNA vaccine against Covid-19 for emergency use.
The three-dose ZyCoV-D vaccine prevented symptomatic disease in 66% of those vaccinated, according to an interim study quoted by the vaccine maker Cadila Healthcare.

The firm plans to make up to 120 million doses of India's second home-grown vaccine every year.

Previous DNA vaccines have worked well in animals but not humans.

India has so far given more than 570 million doses of three previously approved vaccines - Covishield, Covaxin and Sputnik V.
About 13% of adults have been fully vaccinated and 47% have received at least one shot since the beginning of the drive in January.

Cadila Healthcare said it had conducted the largest clinical trial for the vaccine in India so far, involving 28,000 volunteers in more than 50 centres.

This is also the first time, the firm claimed, a Covid-19 vaccine had been tested in young people in India - 1,000 people belonging to the 12-18 age group. The jab was found to be "safe and very well tolerated" in this age group.

The key third phase of clinical trials was conducted at the peak of the deadly second wave of the virus. The vaccine maker believes this reaffirmed the jab's "efficacy against the mutant strains", especially the highly infectious Delta variant.
Zydus Cadilla vaccine
image sourcezydus cadilla
image captionThe firm plans to make up to 120 million doses of the vaccine every year
"I am quite excited about the vaccine because it offers a lot of good potential. If this jab works, the future of vaccination becomes logistically simpler," said Prof Shahid Jameel, a well-known virologist.

How does this vaccine work?​

DNA and RNA are building blocks of life. They are molecules that carry that genetic information which are passed on from parents to children.
Like other vaccines, a DNA vaccine, once administered, teaches the body's immune system to fight the real virus.

ZyCoV-D uses plasmids or small rings of DNA, that contain genetic information, to deliver the jab between two layers of the skin.

The plasmids carry information to the cells to make the "spike protein", which the virus uses to latch on and enter human cells.

Most Covid-19 vaccines work by giving the body instructions to make a fragment of the spike protein so it can trigger a person's immune system to produce antibodies and teach itself to fight off the virus.

What makes this vaccine different?​

This is the world's first human DNA vaccine against Covid-19.

There are a number of DNA vaccines approved in the US, for example, for use in animals, including a vaccine for a disease in horses and a skin cancer vaccine for dogs.

However, more than 160 different DNA vaccines are being tested in human clinical trials in the US. Most are devoted to treating existing cancers, and a third of the vaccines were for treating HIV.

ZyCov-D is also India's first needle-free Covid-19 jab.

It is administered with a disposable needle-free injector, which uses a narrow stream of the fluid to penetrate the skin and deliver the jab to the proper tissue.

"To have a DNA vaccine which works against an infection is a big deal. If it gives good protection this is something India will be proud of," said Dr Gagandeep Kang, a virologist and the first Indian woman to be elected Fellow of the Royal Society of London.

What are the advantages of a DNA vaccine?​

Scientists say DNA vaccines are relatively cheap, safe and stable.

They can also be stored at higher temperatures - 2 to 8C.

Cadila Healthcare claims that their vaccine had shown "good stability" at 25C for at least three months - this would help the vaccine to be transported and stored easily.

What are the drawbacks of a DNA vaccine?​

DNA vaccines developed for infectious diseases in humans have failed in the past.

"The problem is they work well in animals. But they don't end up offering the same level of immune response protection in humans," said Dr Kang.

The challenge, according to Dr Kang, was how to push the plasmid DNA into the human cell so that it gives a durable immune response.
Dr Jeremy Kamil, a virologist at Louisiana State University Health Sciences Center in Shreveport, echoed a similar sentiment.

"Plasmid DNA vaccines have been tried in the past. But we know it's very difficult to get plasmid DNA into the nucleus of human cells, especially in adults," Dr Kamil told me.

mRNA vaccines - which use messenger RNA, a molecule, to make the proteins - like Pfizer or Moderna do not need to reach the nucleus of the cell to be effective and offer higher efficacy and are likely to produce longer lasting immunity.

The other potential drawback is that ZyCoV-D requires three doses, instead of two for the other two candidates being used in India. The vaccine maker says it is evaluating at a two-dose jab.

"I would be delighted that a vaccine company overcame the immense challenges to make it work. But it's imperative that the efficacy data be vetted independently," said Dr Kamil.
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Jun 19, 2019


Senior member
Dec 3, 2017

India hits back after PNG bans flights over COVID ‘deception’​

The Indian embassy in Papua New Guinea (PNG) denies police claims that it helped unauthorised passengers, including four people who were infected with COVID-19, arrive in the Pacific nation’s capital, Port Moresby.

The denial on Tuesday came after PNG Police Commissioner David Manning last week banned all flights from India, accusing the Indian government of “deliberately” participating in “deception” that compromised the island nation’s safety and security.
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The police chief, who is in charge of PNG’s COVID-19 response, also banned Indonesia’s Garuda Airlines and Hong Kong’s CapaJet, a charter company, from using the country’s airspace “until further notice”.

Papua New Guinea’s borders are closed to most travellers because of the COVID-19 pandemic, but Manning said the country allowed a repatriation flight to carry 81 passengers from the Indian capital, New Delhi, into Port Moresby with stringent conditions, including negative tests for COVID-19.

But when the Garuda Airlines flight GA7610 arrived on August 17, the police chief claimed it carried three passengers who were not authorised to travel to PNG.

He also said the Indian government allowed some passengers to board the aircraft without a negative COVID-19 test. “This failure has meant that the flight carried four individuals into Papua New Guinea who are infected with COVID-19,” he said.

Through these actions, India has undermined the trust of a friendly nation, Manning said.

“India must respect Papua New Guinea as a sovereign nation, and not participate in actions involving unscrupulous people, to violate our laws and undermine public health and safety measures.”

The Indian embassy denied the allegations.

“All foreign national passengers onboard the aircraft destined for Port Moresby held valid SOE [State of Emergency] Approvals, Covid PCR Test and Vaccination Certificates,” the mission said in a statement to Al Jazeera.

“Passengers were only given tickets once they had provided the SOE approval, in line with the prescribed guidelines set out by the Controller.”

It also provided documents, including a flight manifest that listed the 84 passengers as well as certificates issued by the PNG government that approved entry for all 84 passengers.

CapaJet – which chartered the Garuda Airlines flight – also denied Manning’s allegations.

“We work with embassies all around the world and are very much aware of capacity and quotas and everything else. It’s part of our standard operating procedure,” said Jay Wan, operations director at CapaJet.

“There were no people on the flight who were not on the manifest. They knew the name of everyone who was coming because we sent a letter to David Manning making sure all the entry conditions were being followed and the PCR results of all the passengers. He replied very clearly with his approval the same day. If a passenger didn’t have their approval, we would not have allowed them to board the flight.”
Wan said he was disappointed by Manning’s actions, especially since CapaJet helped repatriate several PNG diplomats “free of charge” on that same flight.

Adam Delaney, a former PNG diplomat who is now completing doctoral studies at the Australian National University in Canberra, described Manning’s statement as a diplomatic blunder.

“It is not something you flippantly do – publicly accuse countries, India and Indonesia, that have been very good partners to PNG, of acting deceptively. It needs to be addressed quite urgently,” said Delaney.

“It shows that Manning is under lots of stress and the National COVID-19 Controller can’t do its job because of critical shortages of manpower and finances. As a result, a health problem has become a diplomatic issue when it shouldn’t have.”


Senior member
Dec 3, 2017

1.08 Crore Doses And Counting: India's Single-Day Vaccination Milestone​

New Delhi:
India achieved a new vaccination milestone today with the administering of more than 1.08 crore dose in the day. In total, over 65 crore doses have been administered so far in the country.

Today's figures on the Co-WIN website showed 1,08,84,899 doses have been administered so far in the day.

India had achieved the one-crore doses milestone for the first time on August 27 this year.

A total of over 65 crore doses of COVID-19 vaccines have been administered so far across the country, the health ministry said Tuesday.

Of the total 65,03,29,061 doses administered so far, 50,12,44,655 were first doses while 14,90,84,406 were second doses.

6 Comments In the 60+ age group, 13.34 crore people have been vaccinated while 19.76 crore have been vaccinated in the 45-60 age group. In the 18-44 age group, 31.57 crore have been vaccinated so far.