VLS is typically more heavy, if we have enough space on stern for rbu, than using that space for VLS system instead makes more sense longitudinal stress wise, though again there are plethora of other factor in play.
China's 055 destroyers stores their ASBM's in their stern section
About the modular box launcher concept, the problem is the below deck magazine that reloads the launcher, you can't just effortlessly change calibers.
The russian medvedka-2 is a missile that carries a torpedo as its payload, its an equivalent of US arsoc, its not an anti-torpedo defense system its an anti-submarine system , not a similar system as rbu-6000 in spirit that uses salvos of rockets and depth charges.